Windows computers and servers update on a monthly basis. Most of these updates are self-installing and need no other interaction. Sometimes, though, you need to add registry keys to enable or disable additional security settings. I discussed the additional registry keys needed for Spectre and Meltdown protection earlier, but other updates often need additional settings.
One way to learn about these needed registry settings is to read the security bulletin. Your vulnerability scanner might indicate missing protections after it scans your network, too.